Publications by authors named "K Schmidthaler"
The efficacy and safety of preventive allergen immunotherapy (pAIT) in children are currently under investigation. Here, we provide an overview of pAIT with respiratory allergens concerning the prevention of new sensitizations, allergic disease onset and progression as well as further immunomodulatory effects. Three databases were searched for clinical pAIT studies in children.
View Article and Find Full Text PDFDegree of hydrolysis is a poor predictor of the sensitizing capacity of whey- and casein-based hydrolysates in a Brown Norway rat model of cow's milk allergy.
Food Res Int
April 2024
Article Synopsis
- The effectiveness of hydrolyzed cow's milk protein infant formulas in preventing cow's milk allergy (CMA) is debated, with factors like the degree of hydrolysis influencing the risk of sensitization.
- A study compared the immunogenicity and sensitizing capacity of 30 different whey- and casein-based hydrolysates using a rat model, finding whey-based options to be more immunogenic.
- Surface hydrophobicity was identified as a key factor influencing sensitization, suggesting future research should focus on diverse physicochemical properties rather than just the degree of hydrolysis.
Background: The impact of children on the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains uncertain. This study provides an insight into distinct patterns of SARS-CoV-2 household transmission in case of pediatric and adult index cases as well as age-dependent susceptibility to SARS-CoV-2 infection.
Methods: Immune analysis, medical interviewing, and contact tracing of 26 families with confirmed SARS-CoV-2 infection cases have been conducted.
Background: Immunoglobulin E (IgE)-mediated cow's milk allergy (CMA) can be life-threatening and affects up to 3% of children. Hypoallergenic infant formulas based on hydrolyzed cow's milk protein are increasingly considered for therapy and prevention of cow's milk allergy. The aim of this study was to investigate the allergenic activity and ability to induce T cell and cytokine responses of an infant formula based on extensively hydrolyzed cow's milk protein (whey) (eHF, extensively hydrolyzed formula) supplemented with Galactooligosaccharides (GOS) and CECT5716 (LF) to determine its suitability for treatment and prevention of CMA.
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