Publications by authors named "K Schlessman"

Background: The whole Plasmodium falciparum sporozoite (PfSPZ) vaccine is being evaluated for malaria prevention. The vaccine is administered intravenously for maximal efficacy. Direct venous inoculation (DVI) with PfSPZ vaccine has been safe, tolerable, and feasible in adults, but safety data for children and infants are limited.

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Background: The 5A's heuristic (Ask, Assess willingness to change, Advise, Assist, and Arrange followup) has been proposed as a general approach to brief health behavior advice. This study's purpose was to discover the extent to which the 5A's heuristic is used to discuss exercise, diet, and weight loss during adult primary care visits and to test if individuals with a greater body mass index (BMI) or a chronic disease are more likely to receive more-comprehensive advice.

Methods: We performed a cross-sectional direct observation study of 300 family medicine outpatient visits.

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Background: In chronic renal disease, renal tubular epithelial cell (RTC) Fas expression is up-regulated, leading to apoptotic RTC deletion and tubular atrophy. In vitro, cytokine- or hypoxia-induced up-regulation of Fas expression is associated with RTC apoptosis. In contrast, constitutively expressed, low level RTC Fas does not mediate apoptosis, suggesting that Fas may be coupled to expression level-dependent RTC signaling pathways.

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