Publications by authors named "K Scheckenbach"
Using patient-generated health data more efficient and effectively to facilitate the implementation of value-based healthcare in the EU - Innovation report.
Comput Struct Biotechnol J
December 2024
Healthcare services and products are rapidly changing due to the development of new technologies, offering relevant solutions to improve patient outcomes. Patient-Generated Health Data and knowledge-sharing across the European Union (EU) has a great potential of making healthcare provision more effective and efficient by putting the patient at the centre of the healthcare process. While such initiatives have been taken before, a uniting and overarching approach is still missing.
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- Pivotal studies have shown that dupilumab significantly improves nasal polyp scores, symptom scores, and overall quality of life in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).
- A large-scale evaluation at six European centers found that after 24 and 52 weeks of treatment, patient outcomes consistently improved, regardless of demographic factors or prior treatments.
- By the end of the study, a substantial percentage of the patients met improved health criteria, indicating that dupilumab remains effective over time and not influenced by previous sinus surgeries or other major health issues.
Standardised definitions and diagnostic criteria for extranodal extension detected on histopathological examination in head and neck cancer: Head and Neck Cancer International Group consensus recommendations.
Lancet Oncol
July 2024
Article Synopsis
- Detection of extranodal extension (ENE) in head and neck squamous cell carcinoma indicates a poor prognosis, but there's currently a lack of standardized diagnostic criteria and reporting methods in the literature.
- The Head and Neck Cancer International Group organized a modified Delphi process involving 19 pathology experts to establish consensus recommendations for diagnosing and reporting ENE.
- The resulting guidelines, supported by 19 organizations from 34 countries, aim to standardize the diagnosis and improve accuracy in data collection regarding histology detected extranodal extension.
A better understanding of patients' adherence to treatment is a prerequisite to maximize the benefit of healthcare provision for patients, reduce treatment costs, and is a key factor in a variety of subsequent health outcomes. We aim to understand the state of the art of scientific evidence about which factors influence patients' adherence to treatment. A systematic literature review was conducted using PRISMA guidelines in five separate electronic databases of scientific publications: PubMed, PsycINFO (ProQuest), Cochrane library (Ovid), Google Scholar, and Web of Science.
View Article and Find Full Text PDFBackground: Treatment decision-making in oropharyngeal squamous cell carcinoma (OPSCC) includes clinical stage, HPV status, and smoking history. Despite improvements in staging with separation of HPV-positive and -negative OPSCC in AJCC 8th edition (AJCC8), patients are largely treated with a uniform approach, with recent efforts focused on de-intensification in low-risk patients. We have previously shown, in a pooled analysis, that the genomic adjusted radiation dose (GARD) is predictive of radiation treatment benefit and can be used to guide RT dose selection.
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