Anterior Cruciate Ligament Reconstruction Basics: Quadriceps Tendon (All-Soft Tissue) Autograft Preparation-Part 2.

Anterior cruciate ligament reconstruction with quadriceps tendon autograft is a reliable graft option that has recently increased in use. Varying harvesting and graft preparation techniques available and improved technology and implant design continue to make quadricep tendon preparation more efficient and reproducible. In this Technical Note, we describe our preferred technique for all-soft tissue quadriceps tendon autograft preparation after harvest for anterior cruciate ligament reconstruction.

Anterior Cruciate Ligament Reconstruction Basics: Quadriceps Tendon (All-Soft Tissue) Autograft Harvest-Part 1.

Anterior cruciate ligament reconstruction with quadriceps tendon autograft has become increasingly popular for primary and revision anterior cruciate ligament reconstruction surgery. Although there are a variety of techniques available for performing quadriceps tendon autograft harvest for anterior cruciate ligament reconstruction, a minimally invasive, all-soft tissue harvest technique can result in a reproducible, reliable graft while minimizing donor-site morbidity. In this Technical Note, we describe our preferred technique for quadriceps tendon autograft harvest for anterior cruciate ligament reconstruction.

Aptamer-Targeted Dendrimersomes Assembled from Azido-Modified Janus Dendrimers "Clicked" to DNA.

Amphiphilic Janus dendrimers (JDs), synthetic alternatives to lipids, have the potential to expand the scope of nanocarrier delivery systems. JDs self-assemble into vesicles called dendrimersomes, encapsulate both hydrophobic cargo and nucleic acids, and demonstrate enhanced stability in comparison to lipid nanoparticles (LNPs). Here, we report the ability to enhance the cellular uptake of Janus dendrimersomes using DNA aptamers.

Physician Preferences when Selecting Candidates for Lower-Quality Kidney Offers.

Background: In the United States, more than 50% of kidneys in the lowest 15% quality range (those with Kidney Donor Profile Index >85) are discarded. Studies suggest that using more of these kidneys could benefit patients waiting for a transplant. This study assesses the trade-offs physicians make when selecting recipients for lower-quality kidneys.

Kidney organ allocation: reducing discards.

Purpose Of Review: The donation and kidney transplant system in the United States is challenged with reducing the number of kidneys that are procured for transplant but ultimately discarded. That number can reach 20% of donated kidneys each year.

Recent Findings: The reasons for these discards, in the face of overwhelming demand, are multiple.