Publications by authors named "K Schanda"
Article Synopsis
- Myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis (MOG-EM) is an important condition to differentiate from multiple sclerosis and neuromyelitis optica, with new diagnostic criteria emphasizing specific antibody testing.
- This study evaluated the effectiveness of using MOG-IgG3-specific testing in addition to standard tests for detecting MOG antibodies in patients previously identified as having MOG-EM.
- Results showed that MOG-IgG3 could improve the sensitivity of tests, as 52% of patients still displayed positive MOG-IgG3 results, indicating it may be a crucial subclass in diagnosing MOG-EM, despite its absence in healthy controls or
Article Synopsis
- Recent studies suggest that myelin oligodendrocyte glycoprotein antibody-associated disease could be a rare complication linked to either SARS-CoV-2 infection or vaccination.
- The research aims to determine if there's an immune response overlap between SARS-CoV-2 proteins and myelin oligodendrocyte glycoprotein, which could explain the condition's occurrence.
- Serum samples from various groups with different histories of SARS-CoV-2 infection and neurological symptoms were analyzed to assess antibody responses against both myelin oligodendrocyte glycoprotein and SARS-CoV-2, among other common coronaviruses.
Background And Objectives: Glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) serum levels are useful to define disease activity in different neurologic conditions. These biomarkers are increased in patients with aquaporin-4 antibody-positive NMOSD (AQP4+NMOSD) during clinical attacks suggesting a concomitant axonal and glial damage. However, there are contradictory results in double seronegative NMOSD (DS-NMOSD).
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- The study investigates the significance of myelin oligodendrocyte glycoprotein antibody positivity in cerebrospinal fluid (CSF) for diagnosing MOG antibody-associated disease (MOGAD), analyzing data from 11 medical centers.
- A total of 255 patients were evaluated, with 56.8% showing MOG-Abs in both serum and CSF, while others had MOG-Abs present in either serum or CSF only.
- Results indicated that patients with MOG-Abs positive in both serum and CSF experienced worse disability and more frequent motor, sensory, and sphincter symptoms compared to those with only serum positivity.
More Efficient Complement Activation by Anti-Aquaporin-4 Compared With Anti-Myelin Oligodendrocyte Glycoprotein Antibodies.
Neurol Neuroimmunol Neuroinflamm
January 2023
Background And Objectives: The objective was to study complement-mediated cytotoxicity induced by immunoglobulin G (IgG) anti-aquaporin-4 antibodies (AQP4-IgG) and anti-myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) in human serum samples from patients suffering from the rare demyelinating diseases of the CNS neuromyelitis optica spectrum disorder (NMOSD) and MOG-IgG-associated disease (MOGAD).
Methods: A cell-based assay with HEK293A cells expressing different MOG isoforms (MOGαβ) or AQP4-M23 was used. Cells were incubated with human MOG-IgG or AQP4-IgG-positive serum samples together with active or heat-inactivated human complement, and complement-dependent cytotoxicity (CDC) was measured with a lactate dehydrogenase assay.