Publications by authors named "K Schaecher"
Article Synopsis
- * The objective is to explore the relationship between patient-reported physical function scores and HRU in non-surgical CLBP patients within a university health system from 2015 to 2020.
- * By categorizing patients into Low Physical Function (Low-PF) and High Physical Function (High-PF) groups based on their PROMIS-PF scores, the study uses regression analyses to evaluate differences in HRU between these cohorts.
Article Synopsis
- The study compares the effectiveness of home-based vs. office-based phototherapy for psoriasis, highlighting that while office therapy is cost-effective, it’s often hard to access compared to the more patient-preferred home therapy, which lacks sufficient clinical data, especially for those with darker skin.
- Conducted across 42 dermatology practices in the US, the trial involved 783 participants aged 12 and older with psoriasis, who were randomly assigned to either home or office phototherapy for 12 weeks, followed by another 12 weeks of observation.
- Results showed that home phototherapy led to better skin clearance and quality of life improvements, with 32.8% of participants achieving clear skin compared to
In recent years, infectious disease diagnosis has increasingly turned to host-centered approaches as a complement to pathogen-directed ones. The former, however, typically requires the interpretation of complex multiple biomarker datasets to arrive at an informative diagnostic outcome. This report describes a machine learning (ML)-based classification workflow that is intended as a template for researchers seeking to apply ML approaches for developing host-based infectious disease biomarker classifiers.
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- The study aimed to assess the safety, immune response, and effectiveness of the malaria vaccine RTS,S/AS02 when combined with another protein (FMP1) in healthy adults.
- Sixty participants were divided into four groups to receive different vaccine combinations, and results indicated that co-administering RTS,S and FMP1 at the same site decreased RTS,S antibody levels but maintained similar levels of safety and cellular immune response.
- Immunized groups with RTS,S showed about 30% efficacy in preventing malaria after exposure, while the FMP1 alone group did not demonstrate any protective effect.
Precision medicine approaches are receiving increased attention in dermatology, including inflammatory skin diseases. In psoriasis, a precision medicine treatment paradigm could temper the rapid increase in pharmacy costs that have resulted from a tremendous expansion in the number of available biologic drug options. However, without a clear and agreed upon proof of clinical utility in a real-world setting, costly new pharmacotherapies are often burdened with barriers to coverage by payers and ultimately, routine patient care.
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