Publications by authors named "K Sayers"
While the benefits of pair housing have been well documented, less is known about increasing success in adult male macaque pair introductions. In this retrospective study, 95 unfamiliar adult male macaque () pairs were examined to determine whether duration of visual contact, behavior, and age and weight were associated with success rate, with "success" defined as two weeks in full tactile contact without excessive behavioral indicators of incompatibility or injury requiring clinical treatment or care. Overall, the unfamiliar adult male pairs achieved a success rate of 72% and wounding requiring medical attention was rare (2%).
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- Researchers are utilizing genetic diversity in rhesus macaques to better understand human diseases by sequencing 374 genes related to retinal and neurodevelopmental disorders in 1,845 macaques.
- They identified over 47,000 genetic variants, many of which are shared with human populations, and developed a machine learning tool that effectively predicts the pathogenicity of these genetic variants.
- The study includes the identification of a specific model for autosomal dominant optic atrophy and features a public website that provides access to genetic data from over 2,000 rhesus macaques.
Article Synopsis
- The study investigates hybridization among baboons to enhance our understanding of primate evolution, focusing on olive and yellow baboon species at the Southwest National Primate Research Center.
- Researchers used full genome data from 881 baboons to analyze genetic ancestry and improve the quality of genetic markers, discovering historical admixture in some supposedly purebred specimens.
- The findings included the creation of updated genetic maps and a set of 1,747 ancestry informative markers, which show strong agreement in global ancestry estimation but revealed phase switch errors influenced by the methods used.
The marmoset is a fundamental nonhuman primate model for the study of aging, neurobiology, and many other topics. Genetic management of captive marmoset colonies is complicated by frequent chimerism in the blood and other tissues, a lack of tools to enable cost-effective, genome-wide interrogation of variation, and historic mergers and migrations of animals between colonies. We implemented genotype-by-sequencing (GBS) of hair follicle derived DNA (a minimally chimeric DNA source) of 82 marmosets housed at the Southwest National Primate Research Center (SNPRC).
View Article and Find Full Text PDFThe importance of this observation lies in its potential to directly impact testing outcomes and patient care. By identifying improper sample handling as a contributing factor to a substantial number of invalid results, we emphasize the need for meticulous adherence to recommended protocols during sample collection. Laboratories that overlook or are unaware of such deviations may inadvertently compromise the reliability and efficacy of their diagnostic processes, leading to misdiagnoses, delayed treatment, and patient dissatisfaction.
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