Publications by authors named "K Sawanyawisuth"
Article Synopsis
- This study investigates the metabolic differences between on-pump (ONCAB) and off-pump CABG (OPCAB) procedures following heart surgery, as their clinical effects are well known but their metabolomic impacts are less studied.
- In a trial with 20 patients, plasma samples were analyzed pre and post-surgery to find differences in metabolites using advanced techniques, revealing more significant metabolic changes in ONCAB patients, particularly right after surgery.
- Findings indicate that ONCAB leads to higher immediate metabolic disruptions, signaling cellular stress, while supporting the preference for OPCAB in patients at higher metabolic risk due to more stable metabolic outcomes.
Patients presenting with seizure at the emergency department (ED) may have morbidity and mortality. Serum lactate has been shown to be a predictor of diagnosis of seizure versus syncope and mortality in patients presenting with seizure at the ED. There is limited data on using serum lactate as a predictor of the intensive care unit (ICU) admission in patients presenting with seizure at the ED.
View Article and Find Full Text PDFImmune evasion is one of the mechanisms by which cancer cells acquire immunity during cancer development and progression. One of these is the increased expression of cluster of differentiation 47 (CD47), a transmembrane glycoprotein that protects cells from phagocytic elimination. The interaction between CD47 and signal regulatory protein alpha (SIRPα) on macrophages alleviates the phagocytic signal.
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- Overexpression of acetyl-CoA carboxylase 1 (ACC1) is linked to poor outcomes in cholangiocarcinoma (CCA) patients, and reducing ACC1 levels impairs cell growth in lab models.
- The study investigated how inhibiting ACC1 leads to increased protein acetylation, revealing that both genetic knockdown and pharmacological inhibition resulted in hyperacetylated proteins that hindered cell growth and migration.
- The research identified HSP90 as a key acetylated protein and established a connection between protein hyperacetylation and the AKT/GSK3β/Snail pathway, indicating that targeting ACC1 and lysine deacetylases could be effective in treating CCA.
Tuberculous meningitis (TBM) is a common infectious disease of the central nervous system. Detection of cerebrospinal fluid (CSF) adenosine deaminase (ADA) activity for the diagnosis of TBM has a relatively high accuracy. Most previous reports determined ADA levels by following the colorimetric method of Giusti (endpoint assay).
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