A ferrocene-based chemo-dosimeter for colorimetric and electrochemical detection of cyanide and its estimation in cassava flour.

A simple chemo-dosimeter VDP2 bearing a ferrocene moiety was designed, synthesized, and characterized, and exhibited both chromogenic and electrochemical responses selectively for CN in HO-DMSO (9 : 1, v/v) medium. The probe VDP2 showed an instantaneous color change from colorless to yellow with CN that can readily be observed visually. The deprotonation of the benzimidazole -NH, followed by nucleophilic addition of CN to the olefinic C-atom, as evidenced by H and C NMR titration experiments, caused the colorimetric and electrochemical responses.

Spectroscopic and Theoretical Studies on the Selective Detection of Cyanide Ions by a Turn-On Fluorescent Chemo-Dosimeter and its Application in Living Cell Imaging.

A new chemo-dosimeter AK4 containing quinoline fluorophore has rationally been designed, synthesised and characterized using H and C NMR and mass spectral techniques. The probe senses explicitly CN ion through a dramatic enhancement in fluorescence over other commonly coexistent anions in HO:DMSO (9:1 v/v) medium over a broad pH range (4-10). H NMR titration revealed the deprotonation followed by nucleophilic addition reaction of CN, which was supported by C NMR and mass spectral examinations.

Multi-Spectroscopic and TD-DFT Studies on Chromogenic and Fluorogenic Detection of Cyanide in an Aqueous Solution.

Different spectroscopic techniques and Density Functional Theory (DFT)/Time-Dependent Density Functional Theory (TDDFT) calculations have been employed to investigate the dual channel CN detection behaviour of the developed chemo-dosimeter (AK3). The CN with AK3 reaction triggered a colour change from pale yellow to colourless and enhanced fluorescence. UV-Vis, fluorescence, H & C NMR and mass techniques coupled with theoretical calculations (Mulliken charges, dihedral angles) revealed that the CN sensing process mechanism involves deprotonation of the N-H group followed by nucleophilic addition reaction.

Spectroscopic and TD-DFT studies on the chromo-fluorogenic detection of cyanide ions in organic and aquo-organic media.

A new naked-eye chromogenic and fluorogenic probe KS5 has been developed for the detection of CN ions in neat DMSO and HO:DMSO (1:1 v/v) media. The probe KS5 exhibited selectivity towards CN and F ions in organic and high selectivity towards CN ions in aquo-organic media resulting in a colour change from brown to colourless and a turn-on fluorescence response. The probe could able to detect CN ions via a deprotonation process, which was conceived by consecutive addition of hydroxide and hydrogen ions and confirmed using H NMR studies.

A highly selective probe for fluorometric sensing of cyanide in an aqueous solution and its application in quantitative determination and living cell imaging.

A simple fluorescent probe (KS4) containing multiple reaction sites (phenolic -OH, imine and C = C bonds) is successfully synthesized and characterized using H NMR, C NMR, mass and single crystal XRD techniques. KS4 exhibits high selectivity towards CN over a wide range of common anions in HO:DMSO (1:1 v/v) leading to an amazing turn-on fluorescence at 505 nm via deprotonation of the phenolic -OH group. The limit of detection (1.