Publications by authors named "K Saptami"

Urea is one of the major components of the human urine and its breakdown by the uropathogens occurs mainly through the activity of the enzyme urease. However, a few reports suggest the presence of an alternate enzyme system for urea breakdown namely urea carboxylase (UC) and allophanate hydrolase (AH). We have previously reported the UC and AH system in the genome of a urease-negative uropathogen Kalamiella piersonii YU22 of the novel genus Kalamiella (reclassified recently as Pantoea).

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Biofilm formation associated with quorum sensing (QS) is a community behaviour displayed by many gram-negative pathogenic bacteria that provide survival advantages in hostile conditions. The inhibitors of QS interrupt bacterial communication and coordinated cell signalling for community aggregation in the biofilm. Thymol, a natural monoterpenoid, was tested against QS in Chromobacterium violaceum.

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Article Synopsis
  • Halomonas malpeensis strain YU-PRIM-29 is a halophilic bacterium identified for its yellow pigment and ability to produce exopolysaccharides (EPS), which are important for various industrial applications.* -
  • Whole genome sequencing revealed a total of 3,607,821 base pairs with genes related to EPS and capsular polysaccharide biosynthesis, showing that the EPS production is influenced by the carbon source used in cultures.* -
  • Further analysis identified metabolites such as zeaxanthin, which has antioxidant properties, confirming the strain's potential for producing valuable industrial biomolecules.*
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Development of drug resistance in opportunistic pathogens is one of the major healthcare challenges associated with infection management. Combination therapy has many advantages due to the simultaneous action of two drugs on two separate cellular targets. However, selection of the drugs should offer safety and synergistic interaction against most of the strains.

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Silver nanoparticles (AgNPs) have gained attention due to their exceptional physicochemical properties and biological activities, owing to which they are extensively used in biomedical field. We synthesized AgNPs by rapid microwave-assisted method using fucoidan as a reducing agent. The synthesized fucoidan-AgNPs (F-AgNPs) were characterized for the structural and functional properties.

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