Publications by authors named "K Samy"

Normothermic machine perfusion (NMP) facilitates utilization of marginal liver allografts. It remains unknown whether clinical benefits offset additional costs in the real-world setting. We performed a comparison of outcomes and hospitalization costs for donor livers preserved by NMP versus static cold storage (SCS) at a high-volume center.

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Article Synopsis
  • Cyclin-dependent kinases (CDKs) are crucial for regulating the cell cycle, and their alteration in cancer cells leads to uncontrolled growth, making CDK2 a promising target for anticancer drugs.
  • Researchers developed a series of selective small molecule inhibitors for CDK2, utilizing structure-based drug design to optimize potency and selectivity against other kinases like ERK2 and CDK4.
  • One specific compound showed impressive results, achieving a 112% tumor growth inhibition in mice with ovarian cancer (OVCAR3) when administered at a dosage of 50 mg/kg twice daily.
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Sarcomas are a rare tumor of mesenchymal origin. The liposarcoma is the most common sarcoma of the retroperitoneum. Liposarcomas are typically low grade, and present at an advanced stage and a large size.

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