Publications by authors named "K Sakuraba"
Article Synopsis
- - Human salivary amylase levels rise with stress and high-intensity exercise, but the link between the number of AMY1 gene copies and amylase response to exercise is not well understood.
- - In a study with 42 university students, saliva samples collected before and after high-intensity exercise showed a significant increase in amylase activity, correlating positively with AMY1 copy number.
- - The findings indicate that while aerobic fitness and AMY1 copy number impact the increase in amylase activity, gender does not influence this response, suggesting distinct mechanisms for regular and exercise-induced amylase secretion.
Isolated adrenocorticotropic hormone deficiency (IAD) is a rare pituitary disorder that can cause adrenal insufficiency. However, due to its nonspecific symptoms, its diagnosis is often difficult and may be delayed. Patients with IAD require lifelong glucocorticoid (GC) replacement therapy.
View Article and Find Full Text PDFWe studied the effects of rheumatoid arthritis (RA) autoantibodies that target malondialdehyde-acetaldehyde protein adducts (anti-MAA) on inflammation and macrophage functions. We detected a profound reprogramming of gene expressions and the production of chemokines, such as CCL22 and CCL24, in anti-MAA exposed macrophages. Moreover, anti-MAA pretreatment promoted a more inflammatory cytokine profile upon TLR activation.
View Article and Find Full Text PDFArticle Synopsis
- Synovial tissue-resident macrophages (STRMs) are important for maintaining healthy joint function, but their role may change in rheumatoid arthritis (RA) where other inflammatory macrophages are also present.
- The study found that when STRMs were exposed to RA-related stimuli, they did not significantly alter their surface markers like PBMoMs but did change their cytokine gene expression patterns.
- Ultimately, STRMs were shown to promote proinflammatory activity in neighboring cells, suggesting they may contribute to inflammation in RA joints while retaining their normal characteristics.
Objectives: The current study compared the outcome after orthopaedic surgeries in patients with rheumatoid arthritis receiving Janus kinase inhibitors (JAKis) versus biologic disease-modifying anti-rheumatic drugs (bDMARDs).
Methods: This was a retrospective observational study of Japanese patients with rheumatoid arthritis. Sixty-two patients with rheumatoid arthritis using JAKi preoperatively underwent orthopaedic surgeries.