Publications by authors named "K Saks"
Characterization of Pediatric Acute Myeloid Leukemia With t(7;12)(q36;p13).
Genes Chromosomes Cancer
November 2024
Article Synopsis
- Acute myeloid leukemia (AML) with the t(7;12) translocation is common in infants and has been recognized by the WHO, although the exact mechanism behind its development is unclear.
- A study of 12 pediatric AML cases with this translocation found no significant difference in survival rates compared to other AML types, but noted a consistent high expression of MNX1 across all cases.
- Whole transcriptome and genome sequencing revealed various fusion transcripts, primarily involving NOM1, but emphasized the importance of MNX1's overexpression as the key driving factor in this AML subtype.
Hyperleukocytosis in pediatric acute myeloid leukemia (AML) is associated with severe complications and an inferior outcome. We report results on patients with hyperleukocytosis included in the NOPHO-DBH AML 2012 study. We recommended immediate initiation of full-dose chemotherapy (etoposide monotherapy for 5 days as part of the first course), avoiding leukapheresis and prephase chemotherapy.
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- The study investigates the relationship between self-efficacy, goal setting, and learning outcomes, pointing out inconsistencies in prior research.
- Data was gathered from 160 teacher training students using surveys and analysis methods to explore how self-efficacy influences grade goals and academic performance.
- Findings reveal that higher self-efficacy positively impacts students' grade expectations, which, in turn, mediates their overall learning outcomes, emphasizing the importance of motivation in online education.
Purpose: Measurable residual disease (MRD) by using flow cytometry after induction therapy is strongly prognostic in pediatric AML, and hematopoietic stem-cell transplant (hSCT) may counteract a poor response. We designed a phase III study with intensified response-guided induction and MRD-based risk stratification and treated poor induction response with hSCT. The efficacy of liposomal daunorubicin (DNX) in induction was compared with mitoxantrone.
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- A study investigated 66 children with resistant acute myeloid leukaemia (AML) from a larger cohort, revealing that older age (10 years+) and high white-blood-cell counts at diagnosis are significant risk factors for resistant disease.
- The five-year overall survival rate for these patients was found to be only 38%, but among those who achieved complete remission (CR) after salvage chemotherapy, the survival rate rose to 57%.
- The study concluded that nearly 40% of children with primary resistant AML can be successfully treated with salvage therapy followed by allogeneic stem cell transplantation, but additional chemotherapy after two unsuccessful attempts did not improve outcomes.