Publications by authors named "K Sako"
Background/aim: Cancer cachexia is characterized by weight loss with a specific decrease in skeletal muscle and adipose tissue. In Japan, anamorelin, which has a novel mechanism of action, was approved in 2021 for the treatment of cancer cachexia. However, little information is available on its safety in routine clinical care, in particular the occurrence of conduction defects as adverse reactions.
View Article and Find Full Text PDFIntervertebral disc degeneration is a leading cause of chronic low back pain, affecting millions globally. Regenerative medicine, particularly cell-based therapies, presents a promising therapeutic strategy. This study evaluates the comparative efficacy of two biomaterials-hyaluronic acid (HA) and alginate-as carriers for nucleus pulposus (NP) cell transplantation in a beagle model of induced disc degeneration.
View Article and Find Full Text PDFComprehensive electrolyte infusions containing amino acids, including BFLUID, are a source of nosocomial infections caused by . It is recommended that clinicians finish the administration of BFLUID within 6 h; however, this recommendation currently lacks supporting empirical evidence. Accordingly, the present study aimed to investigate the risk of infection associated with BFLUID infusion according to the administration time.
View Article and Find Full Text PDFBackground: This study assessed the association of pathological kidney lesions with cardiovascular events in biopsy-proven diabetic kidney disease (DKD) with type 2 diabetes.
Methods: This multicenter, retrospective study involved 244 patients with no previous cardiovascular events before biopsy, estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73 m at biopsy (baseline), and ≥ 1 year of observation after biopsy.