[Pharmacokinetic parameters as criteria for clinical use of hydroxyethyl starch preparations].

Pharmacokinetic Parameters as Criteria for Clinical Use of Hydroxyethyl Starch Preparations In a study with volunteers (n = 2 x 6) pharmacokinetic data of two only marginally differing starch preparations were investigated. We were able to demonstrate that there exist significant differences in raw materials used which determined the pharmacokinetic data in humans. Newly implemented analyzing methods (LALLS) were used.

[Significance and assessment of the compatibility of mixed solutions with fat emulsion components for parenteral nutrition].

Combined solutions can greatly facilitate the carrying out of parenteral nutrition. The compatibility of their components as well as the stability of such solutions for the duration of clinical use are prerequisites for their application. The necessary and extensive tests of compatibility are illustrated on the basis of a combined solution that is easily produced in the clinic for peripheral and parenteral nutrition.

[Effect of particle size and emulsifier on pharmacokinetic values of a parenterally administered fat emulsion].

To evaluate pharmacokinetic data during parenteral application of a fat emulsion a controlled study in healthy volunteers was performed. Another aim of the study was to investigate whether these kinetics could be changed by modification of the emulsion. For this purpose, 10 male medical students--free of any metabolic disorders--received modified batches of one fat emulsion (Lipovenös), differing with respect to particle size or emulsifier.