Inhaled Anesthetics: Beyond the Operating Room.

The development of inhaled anesthetics (IAs) has a rich history dating back many centuries. In modern times they have played a pivotal role in anesthesia and critical care by allowing deep sedation during periods of critical illness and surgery. In addition to their sedating effects, they have many systemic effects allowing for therapy beyond surgical anesthesia.

Abundant urinary amino acids activate glutamine synthetase-encoding by two different mechanisms in .

Growth of uropathogenic in the bladder induces transcription of which codes for the ammonia-assimilating glutamine synthetase (GS) despite the normally suppressive high ammonia concentration. We previously showed that the major urinary component, urea, induces transcription from the Crp-dependent promoter, but the urea-induced transcript is not translated. Our purpose here was to determine whether the most abundant urinary amino acids, which are known to inhibit GS activity , also affect transcription .

Control of (glutamine synthetase) expression by urea in non-pathogenic and uropathogenic .

The bacteria that cause urinary tract infections often become resistant to antibiotic treatment, and genes expressed during an infection could suggest non-antibiotic targets. During growth in urine, (specifying glutamine synthetase) expression is high, but our results show that urea induces expression independent of the regulation that responds to nitrogen limitation. Although our results suggest that is an unlikely target for therapy because of variation in urinary components between individuals, our analysis of expression in urine-like environments has revealed previously undescribed layers of regulation.

Frequency dependent impedance response analysis of nanocrystalline ZnO chemiresistors.

ZnO is a widely studied gas sensor material and is used in many commercial sensor devices. However, selectivity towards any particular gas remains an issue due to lack of complete knowledge of the gas sensing mechanism of oxide surfaces. In this paper, we have studied the frequency dependent gas sensor response of ZnO nanoparticles of a diameter of nearly 30 nm.