Regional-based static and dynamic alterations in Alzheimer disease: a longitudinal study.

Background:  Alzheimer disease (AD) leads to cognitive decline and alters functional connectivity (FC) in key brain regions. Resting-state functional magnetic resonance imaging (rs-fMRI) assesses these changes using static-FC for overall correlation and dynamic-FC for temporal variability.

Objective:  In AD, there is altered FC compared to normal conditions.

Repurposing Marketed Drugs as Antidepressants with In Silico, In Vivo, and In Vitro Screening Methods.

Drug repurposing is a strategy to identify new therapeutic uses for marketed drugs, discontinued or shelved drugs, and drug candidates in clinical development. Drug repurposing has gained momentum over the past few years. A slow rate of new drug discovery and higher cost of new drug development attracted the attention for repurposing and repositioning of old medications .

Synthesis, properties and antibacterial activity of Ca doped ZnSnO nanoparticles by microwave assisted method.

A major problem in world health care is the development of antibiotic resistance in bacteria. In light of this, pure and calcium-doped zinc tin oxide (ZTO) nanoparticles, ZnSnO (S), ZnSnCaO (S), ZnSnCaO (S), and ZnSnCaO (S), were synthesized via simple and cost effective microwave assisted method. The doping effect on antibacterial activity was studied in detail.

Identification of Attention-Deficit-Hyperactivity Disorder Subtypes Based on Structural MRI Grey Matter Volume and Phenotypic Information.

Background: One of the neurodevelopmental disorders widely affecting school-aged children in recent years is attention deficit hyperactivity disorder (ADHD). In many neurodevelopmental disorders, grey matter may be used as a clinical indicator by looking at MRIs.

Objective: The study aimed to segment grey matter from brain MRI using a proposed fuzzy c-means clustering-based technique for the detection of ADHD and its subtypes (ADHD-Inattentive, ADHDHyperactive, and ADHD-Combined).