Structural basis of human γ-secretase inhibition by anticancer clinical compounds.

Aberrant activation of Notch signaling, mediated by the Notch intracellular domain (NICD), is linked to certain types of cancer. The NICD is released through γ-secretase-mediated cleavage of the Notch receptor. Therefore, development of a γ-secretase inhibitor (GSI) represents an anticancer strategy.

Improvement of adhesive properties of modified epoxy-novolac resin by acrylonitrile-butadiene rubber grafted poly(chromium methacrylate).

The purpose of this work was to improve the adhesive properties of modified epoxy-novolac resin by acrylonitrile-butadiene rubber (NBR) grafted poly(chromium methacrylate). Chromium methacrylate was prepared by reaction of basic chromium sulfate with sodium methacrylate. Acrylonitrile-butadiene rubber grafted poly(chromium methacrylate) (GNBR) was successfully prepared by solution graft copolymerization to improve the adhesive properties of epoxy-novolac resin.

PLMC: Language Model of Protein Sequences Enhances Protein Crystallization Prediction.

X-ray diffraction crystallography has been most widely used for protein three-dimensional (3D) structure determination for which whether proteins are crystallizable is a central prerequisite. Yet, there are a number of procedures during protein crystallization, including protein material production, purification, and crystal production, which take turns affecting the crystallization outcome. Due to the expensive and laborious nature of this multi-stage process, various computational tools have been developed to predict protein crystallization propensity, which is then used to guide the experimental determination.

An unusual etiology of subarachnoid hemorrhage, basilar artery perforator aneurysms, in Macao: Three case reports and review of literature.

Background: Subarachnoid hemorrhage is a severe neurological condition that requires prompt and appropriate treatment to prevent complications. Aneurysms are the most common cause of spontaneous subarachnoid hemorrhage. Conversely, basilar artery perforator aneurysms (BAPAs) are a rare etiology.

Robot-assisted navigation for percutaneous localization of peripheral pulmonary nodule: an swine study.

Background: Robot-assisted surgery (RAS) systems have been developed but rarely applied to lung nodule localization. This study aimed to assess the feasibility and safety of using a robot-assisted navigation system in percutaneous lung nodule localization.

Methods: A computed tomography (CT)-guided robot-assisted navigation system was used to localize the simulated peripheral nodule in the swine lung through fluorescent agent injection.