Publications by authors named "K S Tsang"
Article Synopsis
- Normal tissues adjacent to breast tumors (NATs) may contain early signs of breast cancer development due to a phenomenon called field cancerization.
- A study using advanced genomic techniques on samples from 43 breast cancer patients in Hong Kong revealed that NATs often had single-nucleotide variants (SNVs) in driver genes also found in tumor samples, but rarely had large-scale genomic changes.
- The researchers identified different evolutionary patterns among NAT and tumor pairs, indicating distinct genomic characteristics and the influence of the tumor microenvironment on cancer development.
Article Synopsis
- * A study identified a specific genetic variation at Chr6:31373718C>G that is associated with increased CRC risk, particularly in the younger population, with stronger odds for EOCRC compared to older adults.
- * Analysis showed that individuals carrying the minor G allele have reduced expression of the immune-related MICA gene and lower levels of Natural Killer (NK) cell infiltration in tumors, suggesting a link between this genetic variation and tumor immune response.
Interpreting the phenotypes of alleles in genomes is complex. Whilst all strains are expected to carry a chromosomal copy conferring resistance to ampicillin, they may also carry mutations in chromosomal alleles or additional plasmid-borne alleles that have extended-spectrum β-lactamase (ESBL) activity and/or β-lactamase inhibitor (BLI) resistance activity. In addition, the role of individual mutations/a changes is not completely documented or understood.
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