Publications by authors named "K S Selvaraj"
Article Synopsis
- The study compared two techniques for navigating intranasal scopes during flexible nasopharyngolaryngoscopy (F-NPLS) to assess patient comfort and practitioner satisfaction.
- There was no significant difference in successful first attempts between the two methods, but one method had lower rates of mucosal trauma and bleeding.
- Patients reported more pain during retakes compared to their initial scope procedure, highlighting the need for effective pain management.
Synthesis and antibacterial study of anhydrotetracycline derivatives.
Bioorg Med Chem Lett
December 2024
A novel and new type of tetracycline with a different mechanism of action was necessary, due to the drug resistance of existing tetracyclines. This study outlines the synthesis and antibacterial evaluation of anhydro-tetracycline derivatives, which are unconventional tetracyclines with unique mechanisms of action. These derivatives include C4-NH, C4-OH, and C9-substituted variations, and our synthetic approach focuses on semi-synthesis using natural tetracyclines as the starting precursors.
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- Necrotizing fasciitis (NF) is a serious infection that needs quick diagnosis and treatment; the LRINEC score helps assess patient risk levels early on.
- A study in Chennai involving 112 NF patients found that 51.8% were at low risk, with significant links between higher LRINEC scores and worsening lab results, diabetes, and vascular disease.
- With proper treatment, 83.9% of patients improved with conservative methods, while complications like delayed healing occurred in some cases, highlighting the importance of the LRINEC score in clinical decision-making.
Extraneural perineuriomas are rare, benign soft tissue tumors arising from perineurial cells, which form the protective lining of peripheral nerves. These tumors are infrequently encountered in the foot, posing diagnostic challenges due to their rarity and non-specific clinical presentation. Here, we describe the case of a 45-year-old woman, who had a swelling over the right foot dorsum for four years for which an excision biopsy was done.
View Article and Find Full Text PDFA lumbar hernia is characterized by the protrusion of intra-abdominal contents through a defect in the muscles of the lumbar region. They can be classified as primary or secondary based on their etiology. We present a case of a 65-year-old male who had swelling in the right flank region for nearly 20 years and experienced sudden onset pain over the last 20 days.
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