Oral losartan treatment improves microvascular endothelial function via nitric oxide-dependent mechanisms in women with a history of preeclampsia.

Background: Women with a history of preeclampsia are at increased risk of developing cardiovascular disease compared with women who had a healthy pregnancy. One potential mechanism underlying this increased risk is microvascular endothelial dysfunction, characterized by reduced nitric oxide (NO)-dependent dilation and is mediated, in part, by increased vasoconstrictor sensitivity to angiotensin II, which persists postpartum. We hypothesized that systemic angiotensin II type 1 receptor (AT1R) inhibition via once-daily oral losartan treatment would 1) improve endothelium- and NO-dependent dilation, and 2) reduce angiotensin II-mediated vasoconstriction, in the microvasculature of women with a history of preeclampsia.

Mindfulness and Objective Measures of Body Awareness: A Preregistered Systematic Review and Multilevel Meta-Analysis.

Objective: Bodily sensations are a key element in many mindfulness practices. Previous meta-analytic evidence indicated a small positive association between mindfulness and interoceptive accuracy. The current study aimed to critically extend and update these findings, using all currently available evidence.

Self-Reported Quality of Life and Lived Experiences of Adolescent Cancer Survivors Aged 10-19 in Southwestern Uganda: A Mixed-Methods Study in a Resource-Limited Setting.

Background: Cancer and its management affect the quality of life (QOL) and lived experiences of adolescent survivors.

Aims: We describe the QOL and document the lived experiences of adolescent cancer survivors at a tertiary hospital in southwestern Uganda.

Methods And Results: We conducted a mixed-methods, cross-sectional study using descriptive quantitative interviews using the summarized World Health Organization QOL questionnaire and qualitative in-depth interviews with adolescent cancer survivors at Mbarara Regional Referral Hospital in southwestern Uganda in July and August 2023.

Patterns of outpatient antibiotic prescribing in older adults by social determinants of healthcare access: a population-based retrospective cohort study.

Objectives: Strategies to improve antibiotic use may exacerbate health inequities if they do not consider existing barriers to healthcare access. We examined associations between social determinants of healthcare access (SDOH) and antibiotic prescribing and variations in these associations pre- and post-COVID-19 emergence.

Methods: We conducted a retrospective cohort study of community-dwelling adults ≥66 years of age in Ontario, Canada between March 2018 to March 2020 (pre-pandemic period) and March 2020 to March 2022 (pandemic period).

Cactus Thorn Knee Injuries in Children: A Report of 3 Cases.

Case: Three cases of pediatric patients with knee injuries from cactus thorns are included. These cases are variable in presentation ranging from acute inflammatory responses to permanent limb deformity secondary to growth arrest. Definitive treatment also varied widely from nonoperative conservative management to multiple arthroscopic and open surgeries.