Publications by authors named "K S Sardana"
Introduction: Methotrexate (MTX) acts by suppressing multiple immune pathways involved in the pathogenesis of lichen planus (LP). Trials assessing the efficacy and relapse rates of methotrexate in LP are lacking.
Objectives: Our objective was to analyze the efficacy and safety of low-dose methotrexate in generalized and recalcitrant LP patients retrospectively and to assess the relapse rates in patients after stopping MTX therapy.
There are conflicting reports regarding the roles of T helper-17 (Th17) and T regulatory (Treg) cells in type 1 leprosy reactions (T1Rs). Also, literature on the correlation of immunological parameters with a validated scoring system and the effect of treatment on cytokines is lacking. Adult patients with untreated T1R and nonreactional spectrum-matched controls were included in the study for comparison of levels of Th17 and Treg pathway cytokines in serum, skin lesions (reactional), and peripheral blood mononuclear cells (PBMCs) culture supernatants.
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- * A study analyzed tissue samples from 11 patients with difficult-to-treat CHE, finding increased levels of key cytokines (IL-4, TNF-α, IFN-γ) compared to unaffected skin.
- * Tofacitinib was administered to 15 patients, showing promising results with a mean improvement in eczema severity after 4 weeks, although some experienced side effects and relapses after stopping treatment.
A study of T regulatory cells in type 1 and type 2 leprosy reactions.
Indian J Dermatol Venereol Leprol
September 2024