Publications by authors named "K S Santangelo"
Article Synopsis
- The study investigates the relationship between metabolic disorders and rotator cuff injuries, focusing on how different types of injuries (acute tears vs. chronic degeneration) affect tendon metabolite profiles.
- Using untargeted metabolomics, researchers discovered that acute tears led to decreased levels of metabolites, particularly glycolic acid and TCA cycle activity, while chronic degeneration was associated with increased amino acids like alanine and proline.
- The findings suggest that different injury types have unique metabolite profiles, highlighting the need for targeted therapeutic strategies that address both cellular and matrix changes in rotator cuff injuries.
Background: Several tissues contribute to the onset and advancement of knee osteoarthritis (OA). One tissue type that is worthy of closer evaluation, particularly in the context of sex, is the infrapatellar fat pad (IFP). We previously demonstrated that removal of the IFP had short-term beneficial effects for a cohort of male Dunkin-Hartley guinea pigs.
View Article and Find Full Text PDFBackground: Lactate measurements have been utilized as diagnostic and prognostic tools for a variety of veterinary species. Reference intervals for lactate have not been published or validated in guinea pigs.
Methods: Whole blood from 48 anesthetized laboratory guinea pigs (46 Dunkin Hartley [38 males, eight females]; two Strain 13 [two males]) was analyzed using two point of care instruments (iSTAT and Lactate Plus).
Aim: Alzheimer's disease (AD) is the most common form of dementia. However, while 150+ animal models of AD exist, drug translation from preclinical models to humans for treatment usually fails. One factor contributing to low translation is likely the absence of neurodegenerative models that also encompass the multi-morbidities of human aging.
View Article and Find Full Text PDFLow back pain poses a significant societal burden, with progressive intervertebral disc degeneration (IDD) emerging as a pivotal contributor to chronic pain. Improved animal models of progressive IDD are needed to comprehensively investigate new diagnostic and therapeutic approaches to managing IDD. Recent studies underscore the immune system's involvement in IDD, particularly with regards to the role of immune privileged tissues such as the nucleus pulposus (NP) becoming an immune targeting following initial disc injury.
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