Publications by authors named "K S Sachdeva"
We studied the correlation between changes in the interscrew angle (screw divergence) and the correction achieved with tension band plates applied for valgus deformities of the knee region. Twenty-eight children with 68 operated physes were included in this retrospective review. The interscrew angle and screw trajectory angle were measured in the initial and follow-up radiographs.
View Article and Find Full Text PDFTuberculosis continues to be among the leading causes of morbidity as well as mortality. It is appreciated that our aim of eliminating TB in the foreseeable future will not be realized until we have a new vaccine with significant efficacy among diverse populations and all age-groups. Although impressive strides have been made in more refined development of new TB vaccines based on learnings from past experiences, the substitute or a booster vaccine for the BCG vaccine is not available yet.
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- Dysfunction in the endolysosomal system is a key characteristic of Alzheimer's disease (AD), particularly due to the hyperactivity of the rab5 protein, impacting neuronal function.
- Researchers created a mouse model that over-expresses APPL1, a protein involved in regulating rab5 activity, leading to enlarged early endosomes and increased synaptic endocytosis.
- The study found that elevated levels of APPL1 resulted in negative effects on memory and synaptic function, emphasizing the role of endosomal dysregulation in the development of AD-related changes in neurons.*
Introduction: Radical prostatectomy is appropriate for any patient whose cancer appears clinically localised to prostate. However because of potential perioperative morbidity, radical prostatectomy is generally reserved for patients whose life expectancy is more than ten years. Moderate hypofractionation for localized prostate cancer is safe and effective.
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