The bioconjugates of curcumin, zingerone and [6]-shogaol with low molecular weight chitosan: Synthesis, characterization and in vitro anticancer activity in HepG2 cells.

The synthesis of bioconjugates of curcumin, zingerone, and [6]-shogaol with low molecular weight chitosan (LMWC) is presented. The unconjugated forms of these compounds exhibit low water solubility, poor stability, limited bioavailability, and low target specificity, whereas the synthetic conjugates demonstrate improved physical properties. The synthesis was achieved by forming succinates & then reacting with LMWC.

Synergistic Strengthening Mechanisms of Dual-Phase (TiN+AlN) Reinforced Aluminum Matrix Composites Prepared by Laser Powder Bed Fusion.

Dual-phase reinforcing approach provides a novel and efficient strategy for the fabrication of advanced aluminum matrix composites (AMCs). The devisable and desirable performance could be achieved by tuning dual-phase reinforcing system. However, it is still challenging to design a dual-phase reinforcing system with synergistic strengthening effect, especially for the laser powder bed fusion (LPBF) characterized by nonequilibrium metallurgical process.

In Vivo Assessment of a Triple Periodic Minimal Surface Based Biomimmetic Gyroid as an Implant Material in a Rabbit Tibia Model.

Biomimetic approaches to implant construction are a rising frontier in implantology. Triple Periodic Minimal Surface (TPMS)-based additively manufactured gyroid structures offer a mean curvature of zero, rendering this structure an ideal porous architecture. Previous studies have demonstrated the ability of these structures to effectively mimic the mechanical cues required for optimal implant construction.

Biofilm Formation on Denture Base Material Reinforced With a Novel Organic Material.

Background: Microcrystalline cellulose (MCC) is a novel organic material developed by one of the authors in this study. When MCC was incorporated with conventionally available denture base resin, it demonstrated increased flexural strength and flexural modulus. However, it was speculated that because the material is organic, it can promote the growth of .