Publications by authors named "K S McKim"
Article Synopsis
- Mitosis and meiosis use error correction and the spindle assembly checkpoint (SAC) to ensure proper chromosome segregation, with recent research focusing on SAC proteins during oocyte meiosis I.! -
- Evidence shows that certain SAC proteins respond to microtubule depolymerization but do not activate in cases of improper chromosomal attachments, indicating other regulatory mechanisms may be at play.! -
- Specifically, proteins ROD and MPS1 play key roles in correcting errors related to homologous chromosome biorientation, and their functions appear to be influenced by specific regions of another protein, SPC105R, while also being independent of dynein adaptor Spindly under certain conditions.!
The reductional division of meiosis I requires the separation of chromosome pairs towards opposite poles. We have previously implicated the outer kinetochore protein SPC105R/KNL1 in driving meiosis I chromosome segregation through lateral attachments to microtubules and coorientation of sister centromeres. To identify the domains of SPC105R that are critical for meiotic chromosome segregation, an RNAi-resistant gene expression system was developed.
View Article and Find Full Text PDFThe reductional division of meiosis I requires the separation of chromosome pairs towards opposite poles. We have previously implicated the outer kinetochore protein SPC105R/KNL1 in driving meiosis I chromosome segregation through lateral attachments to microtubules and co-orientation of sister centromeres. To identify the domains of SPC105R that are critical for meiotic chromosome segregation, an RNAi-resistant gene expression system was developed.
View Article and Find Full Text PDFReproductive success requires the development of viable oocytes and the accurate segregation of chromosomes during meiosis. Failure to segregate chromosomes properly can lead to infertility, miscarriages, or developmental disorders. A variety of factors contribute to accurate chromosome segregation and oocyte development, such as spindle assembly and sister chromatid cohesion.
View Article and Find Full Text PDF