Evidence for a specific distortion in perceptual body image in eating disorders: A replication and extension.

A core feature of eating disorders, such as anorexia nervosa, is an overestimation of body size. A key question is whether this overestimation arises solely from body image concerns typical in eating disorders, or if there is an additional perceptual disturbance. To address this question, we applied a two-component model of body size estimation that has been thoroughly replicated in the body image literature concerning healthy individuals.

Calcineurin/NFAT inhibitors maintain cognition in a preclinical prevention study in an aging canine model of Alzheimer disease.

Brain signaling of calcineurin (CN) and nuclear factor of activated T-cells (NFAT) transcription factor increases in Alzheimer disease (AD) and is associated with synaptic loss, neurodegeneration, neuroinflammation, amyloid-β (Aβ) production, and cognitive decline. CN/NFAT inhibitors ameliorate these neuropathologies in mouse models of AD. Further, chronic use of tacrolimus in transplant patients reduces risk of AD.

Updates on Mechanisms of Cytochrome P450 Catalysis of Complex Steroid Oxidations.

Cytochrome P450 (P450) enzymes dominate steroid metabolism. In general, the simple C-hydroxylation reactions are mechanistically straightforward and are generally agreed to involve a perferryl oxygen species (formally FeO). Several of the steroid transformations are more complex and involve C-C bond scission.

Personal ideal, cultural ideal and optimal attractiveness: Are these constructs for body size and shape the same or different?

There has been an assumption in the literature that the three concepts of ideal body shape (personal ideal, cultural ideal, and the most attractive body shape) are effectively the same percept. To test this presumption, 554 participants completed either a between- or within-subjects condition using a matrix of 32 bodies varying in two dimensions: muscle and adiposity. Three separate groups of participants were recruited to the between-subjects design and made only one of these judgements, whilst participants in the within-subjects version completed all three of these judgments.

Testing the validity of online psychophysical measurement of body image perception.

This body image study tests the viability of transferring a complex psychophysical paradigm from a controlled in-person laboratory task to an online environment. 172 female participants made online judgements about their own body size when viewing images of computer-generated female bodies presented in either in front-view or at 45-degrees in a method of adjustment (MOA) paradigm. The results of these judgements were then compared to the results of two laboratory-based studies (with 96 and 40 female participants respectively) to establish three key findings.