Publications by authors named "K S Lamb"
Genetic disruption of the RAS binding domain (RBD) of PI 3-kinase (PI3K) prevents the growth of mutant RAS driven tumors in mice and does not impact PI3K's role in insulin mediated control of glucose homeostasis. Selectively blocking the RAS-PI3K interaction may represent an attractive strategy for treating RAS-dependent cancers as it would avoid the toxicity associated with inhibitors of PI3K lipid kinase activity such as alpelisib. Here we report compounds that bind covalently to cysteine 242 in the RBD of PI3K p110α and block the ability of RAS to activate PI3K activity.
View Article and Find Full Text PDFObjectives: Waitlist times for adolescents to be seen for initial assessment for gender-affirming hormone therapy in Manitoba, Canada are often 2 years. The purpose of this study was to understand the experiences of waitlisted youth and to assess the impact of social work contact for accessing relevant resources.
Methods: A qualitative, semi-structured interview study was conducted.
Effect of a 48-Hour Thickened Liquid Protocol on Visuospatial Skills in Young Adults.
Folia Phoniatr Logop
December 2024
Article Synopsis
- * In a study with 20 young adults (ages 19-26), researchers measured hydration status and visuospatial skills before and after a 48-hour period of consuming nectar-thick liquids.
- * Results showed that while participants didn't perform worse in terms of accuracy on visuospatial tasks, they took longer to complete them and showed signs of mild dehydration, as indicated by higher urine specific gravity levels.
Two routes to assemble the complete tricyclic core of alopecurone C are described. In the first-generation route, an efficient synthesis of the "eastern" half of the target, including a decagram-scale rhodium-catalyzed C-H insertion reaction, was developed. When this route proved intractable for assembling the final flavanone ring, a successful second-generation route was developed from a flavanone precursor (naringenin) employing a later stage C-H insertion.
View Article and Find Full Text PDFImportance: Patients with lung cancer have poor physical functioning and quality of life. Despite promising outcomes for those who undertake exercise programs, implementation into practice of previously tested hospital-based programs is rare.
Objective: To evaluate a home-based exercise and self-management program for patients after lung resection.