Assessing the need for specialty consultation for isolated medial orbital wall fractures.

Objective: This objective was to assess if the current practice of interfacility transfer and immediate specialty consult is justified by the rate of surgical repair for isolated medial orbital wall fractures.

Study Design: This is a retrospective descriptive study utilizing the records of all patients with isolated medial orbital wall fractures who presented to the ED at Boston Medical Center from January 2014 to December 2022. A descriptive analysis was completed.

Autophagy Modulates Glioblastoma Cell Sensitivity to Selinexor-mediated XPO1 inhibition.

Background: Selinexor is a selective inhibitor of exportin-1 (XPO1), a key mediator of the nucleocytoplasmic transport for molecules critical to tumor cell survival. Selinexor's lethality is generally associated with the induction of apoptosis, and in some cases, with autophagy-induced apoptosis. We performed this study to determine Selinexor's action in glioblastoma (GBM) cells, which are notoriously resistant to apoptosis.

Tunable on-chip optical traps for levitating particles based on single-layer metasurface.

Optically levitated multiple nanoparticles have emerged as a platform for studying complex fundamental physics such as non-equilibrium phenomena, quantum entanglement, and light-matter interaction, which could be applied for sensing weak forces and torques with high sensitivity and accuracy. An optical trapping landscape of increased complexity is needed to engineer the interaction between levitated particles beyond the single harmonic trap. However, existing platforms based on spatial light modulators for studying interactions between levitated particles suffered from low efficiency, instability at focal points, the complexity of optical systems, and the scalability for sensing applications.

Nonclassical Spin-Multiplexing Metasurfaces Enabled Multifunctional Meta-Scope.

Dielectric metasurfaces have emerged as attractive devices for advanced imaging systems because of their high efficiency, ability of wavefront manipulation, and lightweight. The classical spin-multiplexing metasurfaces can only provide two orthogonal circular polarization channels and require high phase contrast which limits their applications. Here, metasurfaces with arbitrary three independent channels are demonstrated by proposing a nonclassical spin-multiplexing approach exploring the low refractive index meta-atoms.

Sirtuin 5 (SIRT5) Suppresses Tumor Growth by Regulating Mitochondrial Metabolism and Synaptic Remodeling in Gliomas.

Sirtuin 5 (SIRT5) is increasingly recognized as a key regulator of cellular metabolism, which is commonly dysregulated in cancer cells, resulting in enhanced proliferation and tumor progression. To investigate the clinicopathologic implications of SIRT5 dysregulation in glioblastoma, we performed comprehensive analyses of transcriptomic data and functional verifications using in vitro and in vivo glioblastoma models. We found that higher SIRT5 expression levels were associated with a favorable prognosis in glioma patients.