Publications by authors named "K S Ingram"
Background/objectives: The circadian clockwork is implicated in the etiology of addiction, with circadian rhythm disruptions bidirectionally linked to substance abuse, but the molecular mechanisms that underlie this connection are not well known.
Methods: Here, we use machine learning to reveal sex- and substance-specific associations with addiction in variants from 51 circadian-related genes (156,702 SNPs) in 98,800 participants from a UK Biobank cohort. We further analyze SNP associations in a subset of the cohort for substance-specific addictions (alcohol, illicit drugs (narcotics), and prescription drugs (opioids)).
Article Synopsis
- Researchers found that the subseafloor crust harbors not only microbes and viruses, but also animals like the giant tubeworm Riftia pachyptila, suggesting a link between seafloor and subseafloor ecosystems.
- The study proposes that tubeworm larvae may travel through the hydrothermal vent fluid rather than dispersing in the open water.
- The discovery of these animals in the subseafloor has significant implications for understanding geochemical processes and highlights the necessity of protecting these habitats, which are not yet fully understood.
species predominate the human vagina and are associated with positive vaginal health, including an acidic pH (<4.5). The prevalence of vaginal increases with increased oestrogen due to increased glycogen production within the vagina.
View Article and Find Full Text PDFIntroduction: Research has illustrated the presence of a diverse range of microbiota in human milk. The composition of the milk microbiome varies across different stages of lactation, emphasizing the need to consider the lactation stage when studying its composition. Additionally, the transfer of both milk and skin microbiota during breastfeeding is crucial for understanding their collective impact on infant health and development.
View Article and Find Full Text PDFIntroduction: Many people with COPD experience frailty. Frailty increases risk of poor health outcomes, including non-completion of pulmonary rehabilitation. Integrated approaches to support people with COPD and frailty throughout and following rehabilitation are indicated.
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