Publications by authors named "K S Haghighi"
Article Synopsis
- - The study examined the prevalence of sleep disorders in 103 patients with systemic scleroderma (SSc) and how these disorders relate to various socio-demographic and medical factors over a period of seven months.
- - Findings indicated that a significant portion of SSc patients (68%) experienced poor sleep quality, particularly linked to skin stiffness, the presence of telangiectasia, interstitial lung disease (ILD), and various demographic factors like age and disease duration.
- - It also found that obstructive sleep apnea and insomnia were notably associated with telangiectasia, ILD, and age, suggesting the need for better disease management strategies to enhance patients' quality of life.
Aims: The aim is to report the results of Australia's first uterus transplantation (UTx).
Methods: Following long-standing collaboration between the Swedish and Australian teams, Human Research Ethics approval was obtained to perform six UTx procedures in a collaborative multi-site research study (Western Sydney Local District Health 2019/ETH13038), including Royal Hospital for Women, Prince of Wales Hospital, and Westmead Hospital in New Souh Wales. Surgeries were approved in both the live donor (LD) and deceased donor models in collaboration with the inaugural Swedish UTx team.
Phospholamban () is a major regulator of cardiac contractility, and human mutations in this gene give rise to inherited cardiomyopathies. The deletion of Arginine 14 is the most-prevalent cardiomyopathy-related mutation, and it has been linked to arrhythmogenesis and early death. Studies in -humanized mutant mice indicated an increased propensity to arrhythmias, but the underlying cellular mechanisms associated with R14del- cardiac dysfunction in the absence of any apparent structural remodeling remain unclear.
View Article and Find Full Text PDFArrhythmogenic cardiomyopathy (ACM) is characterized by life-threatening ventricular arrhythmias and sudden cardiac death and affects hundreds of thousands of patients worldwide. The deletion of Arginine 14 (p.R14del) in the phospholamban (PLN) gene has been implicated in the pathogenesis of ACM.
View Article and Find Full Text PDFStudy Objectives: Restless legs syndrome (RLS) is a sleep-related movement disorder, often accompanied by sleep disruption. Obstructive sleep apnea (OSA) has a controversial prevalence among patients with RLS. We evaluated the clinical and sleep features of patients who attended our sleep clinic considering RLS and OSA.
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