Publications by authors named "K S Emanuel"
The primary immune constituents in the brain, microglia and macrophages, are the target for HIV in people and simian immunodeficiency virus (SIV) in nonhuman primates. This infection can lead to neurological dysfunction, known as HIV-associated neurocognitive disorder (HAND). Given the gaps in our knowledge on how these cells respond in vivo to CNS infection, we perform single-cell multiomic sequencing, including gene expression and ATAC-seq, on myeloid cells from the brains of rhesus macaques with SIV-induced encephalitis (SIVE) as well as uninfected controls.
View Article and Find Full Text PDFObjectives: Cartilage defects (CDs) are regarded as early manifestation of osteoarthritis (OA). The infrapatellar fat pad (IPFP) is an important mediator in maintaining joint homeostasis, disease progression and tissue repair, with a crucial role of its secreted proteins. Here, we investigate the proteome of the IPFP in relation to clinical status and response to surgical treatment of CDs.
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- - Parkinson's disease (PD) is primarily caused by the loss of dopamine-producing neurons in the brain, with mutations in the Pink1 and Parkin proteins linked to familial cases of PD.
- - Recent findings show that Pink1 and Parkin also play a role in how peripheral blood cells (PBMCs) manage energy metabolism, impacting immune cell populations by increasing CD4+ T cells while decreasing CD8+ T cells and B cells in rats.
- - The deficiency of Pink1/Parkin contributes to higher platelet counts and increased aggregation of platelets with lymphocytes, which raises the risk of thrombosis, indicating that targeting these proteins could lead to new therapeutic strategies for PD.
The primary immune constituents in the brain, microglia and macrophages, are the target for HIV in people and simian immunodeficiency virus (SIV) in nonhuman primates. This infection can lead to neurological dysfunction, known as HIV-associated neurocognitive disorder (HAND). Given the gaps in our knowledge on how these cells respond in vivo to CNS infection, we performed single-cell multiomic sequencing, including gene expression and ATAC-seq, on myeloid cells from the brains of rhesus macaques with SIV-induced encephalitis (SIVE) as well as uninfected controls.
View Article and Find Full Text PDF