Spontaneous ventilation video-assisted thoracoscopic surgery for octogenarian non-small cell lung cancer patients: a non-inferiority study.

Background: The benefits of spontaneous ventilation (SV)-video-assisted thoracoscopic surgery (VATS) in octogenarian patients with non-small-cell lung cancer (NSCLC) have rarely been reported. This retrospective study was conducted to evaluate the safety and feasibility of SV-VATS in octogenarian patients with NSCLC.

Methods: Patients with NSCLC aged >80 years who underwent SV-VATS or mechanical ventilation (MV)-VATS between 2017 and 2022 were included in this study.

ABCA6 Regulates Chondrogenesis and Inhibits Joint Degeneration via Orchestrated Cholesterol Efflux and Cellular Senescence.

Patellar dysplasia (PD) can cause patellar dislocation and subsequent osteoarthritis (OA) development. Herein, a novel ABCA6 mutation contributing to a four-generation family with familiar patellar dysplasia (FPD) is identified. In this study, whole exome sequencing (WES) and genetic linkage analysis across a four-generation lineage presenting with six cases of FPD are conducted.

High-performance amino-crosslinked phosphorylated microcrystalline cellulose/MoS hybrid aerogel for polystyrene nanoplastics removal from aqueous environments.

Currently, the development of high-performance adsorbents for the removal of nanoplastics in complex aquatic environments is challenging. In this study, a functionalized polyethyleneimine-phosphorylated microcrystalline cellulose/MoS (PEI-PMCC/MoS) hybrid aerogel was prepared and applied to remove carboxyl-modified polystyrene (PS-COOH) nanoplastics from the aqueous solution. Benefiting from the introduced functional groups and the expanded lamellar structure in MoS nanosheets as well as the highly porous 3D structure of the aerogel, PEI-PMCC/MoS demonstrated high efficiency in PS-COOH nanoplastics removal, achieving a 402.

Mitochondria and the Repurposing of Diabetes Drugs for Off-Label Health Benefits.

This review describes our current understanding of the role of the mitochondria in the repurposing of the anti-diabetes drugs metformin, gliclazide, GLP-1 receptor agonists, and SGLT2 inhibitors for additional clinical benefits regarding unhealthy aging, long COVID, mental neurogenerative disorders, and obesity. Metformin, the most prominent of these diabetes drugs, has been called the "Drug of Miracles and Wonders," as clinical trials have found it to be beneficial for human patients suffering from these maladies. To promote viral replication in all infected human cells, SARS-CoV-2 stimulates the infected liver cells to produce glucose and to export it into the blood stream, which can cause diabetes in long COVID patients, and metformin, which reduces the levels of glucose in the blood, was shown to cut the incidence rate of long COVID in half for all patients recovering from SARS-CoV-2.