Publications by authors named "K S Burgdorf"
Impact of CCR5Δ32 on the risk of infection, Staphylococcus aureus carriage, and plasma concentrations of chemokines in Danish blood donors.
EBioMedicine
November 2024
Article Synopsis
- The CCR5 receptor is linked to susceptibility to Staphylococcus aureus leukotoxin ED, and researchers investigated the effects of the CCR5Δ32 deletion on S. aureus infection and nasal carriage in a large Danish blood donor study.
- Analysis involved over 95,000 participants, examining various health outcomes and inflammatory markers through sophisticated statistical methods.
- Findings indicated that CCR5Δ32 does not significantly affect the risk of S. aureus-related infections or nasal carriage, although it was associated with higher levels of certain chemokines in individuals with the deletion.
Developmental language disorder (DLD) is a neurodevelopmental disorder primarily affecting language in the absence of a known biomedical condition, which may have a large impact on a person's life and mental health. Family-based studies indicate a strong genetic component in DLD, but genetic studies of DLD are scarce. In this study we estimated the heritability of DLD and its genetic correlations with related disorders and traits in sample of >25,000 individuals from the Danish Blood Donor Study for whom we had both genotype data and questionnaire data on language disorder and language support.
View Article and Find Full Text PDFAims/hypothesis: Metabolic risk factors and plasma biomarkers for diabetes have previously been shown to change prior to a clinical diabetes diagnosis. However, these markers only cover a small subset of molecular biomarkers linked to the disease. In this study, we aimed to profile a more comprehensive set of molecular biomarkers and explore their temporal association with incident diabetes.
View Article and Find Full Text PDFHeadache disorders are the most common disorders of the nervous system. The lifetime prevalence of headache disorders show that some individuals never experience headache. The etiology of complete freedom from headache is not known.
View Article and Find Full Text PDFBackground: The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences.
Methods: A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking.