Ultrastructural changes in 9-day old mouse embryos following maternal tobacco smoke inhalation.

Mice were exposed to tobacco smoke inhalation for three ten-minute episodes on days 6, 7 and 8 of pregnancy. The effects of a higher tar cigarette (tar 12.9 mg, nicotine 1.

Effects of tobacco smoke inhalation on the developing mouse embryo and fetus.

Pregnant C57BL or mutant curly tail mice were exposed to tobacco smoke in a smoking machine for 10 min, three times a day, either on the day of conception (day 0) and days 1 and 2, or on days 3, 4, and 5, or from day 0 through day 17. In the first two cases, the embryonic development was subsequently assessed on day 9. Both periods of exposure were associated with a dose-related retardation in embryonic growth, but it was more marked with exposure on days 0, 1, and 2.