Publications by authors named "K S Blum"
Availability of toxicological data for pharmaceutical intermediates (IMs) used in the manufacture of small molecules is often limited. Scarcity of data - in particular, repeat-dose toxicity (RDT) - renders the calculation of health-based exposure limits (HBELs) problematic. Establishment of HBELs, including occupational exposure limits (OELs) and permitted daily exposures (PDEs) facilitating worker and patient safety respectively, is however essential.
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- - The paper discusses the importance of intervention and implementation fidelity in healthcare research, emphasizing that strict adherence to core components of interventions is crucial for meaningful evaluation of outcomes.
- - It highlights the need for flexibility in defining fidelity, as varying contexts and implementation strategies require researchers to adapt their approaches while ensuring that fidelity criteria are transparent and context-dependent.
- - The authors argue that fidelity assessments should consider not just individual behaviors, but also organizational and system factors, further complicating the evaluation process and necessitating a deeper understanding of fidelity concepts.
Article Synopsis
- The opioid crisis has evolved into a global issue affecting various socioeconomic and cultural areas, with traditional treatment methods proving insufficient.
- A narrative review was conducted using multiple databases to explore the complex factors contributing to this epidemic, acknowledging the potential for bias in article selection.
- Despite some progress with Opioid Substitution Therapy, U.S. overdose deaths remain alarmingly high and are projected to increase; the authors suggest a need for a new treatment approach that targets brain neurotransmitter systems for better management.
Article Synopsis
- Borderline personality disorder (BPD) and post-traumatic stress disorder (PTSD) share similar neurobiological features, suggesting that BPD might be better classified as "traumatic personality stress disorder" (TPSD).
- The study explores how psychedelic-assisted therapy (PAT) could effectively treat both BPD and PTSD, emphasizing its role in stabilizing reward functions.
- Reclassifying BPD as TPSD may lead to more personalized treatment approaches, reduce stigma, and improve understanding and management of related psychological conditions.