Publications by authors named "K S Binder"
Article Synopsis
- Immune checkpoint inhibitors (ICIs) are a key treatment for melanoma but can cause pancreatic injury, which is not well-studied or managed.* -
- A study involving 1516 melanoma patients found that 204 experienced elevated lipase levels, with many showing symptoms of pancreatitis, leading to treatment interruptions for nearly half of them.* -
- Despite the lack of guidelines recommending routine lipase monitoring, it was performed in the study, revealing higher-than-expected rates of elevation, particularly in symptomatic patients.*
Gut microbiota-derived metabolites play a pivotal role in the maintenance of intestinal immune homeostasis. Here, we demonstrate that the human commensal possesses a specific metabolic fingerprint, consisting predominantly of the tryptophan catabolite indole-3-propionic acid (IPA), the branched-chain acids (BCFAs) isobutyrate and isovalerate and the short-chain fatty acids (SCFAs) acetate and propionate. Mono-colonization of germ-free mice with (CS mice) affected colonic mucosal immune cell phenotypes, including up-regulation of gene expression, and increased abundance of transcriptionally active colonic tuft cells and Foxp3 regulatory T cells (Tregs).
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- Taking a reading comprehension (RC) test involves answering questions correctly, which reflects students' ability to understand texts, but various test-taking strategies can hinder comprehension.
- A study with 248 students used eye-tracking to observe how they read test questions, discovering connections between eye movements and reading achievement.
- Findings highlight that the challenges faced by less-skilled readers extend beyond the text itself, indicating the need for better strategies in teaching students how to approach RC questions effectively.
Finite size scaling for a first order phase transition, where a continuous symmetry is broken, is tested using an approximation of Gaussian probability distributions with a phenomenological "degeneracy" factor. Predictions are compared to the data from Monte Carlo simulations of the Lebwohl-Lasher model on L × L × L simple cubic lattices. The data show that the intersection of the fourth-order cumulant of the order parameter for different lattice sizes can be expressed in terms of the relative degeneracy q = 4π of the ordered and disordered phases.
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