Therapeutic potential of SMAD7 targeting miRNA in the pathogenesis of diabetic nephropathy.

Diabetic nephropathy (DN) is a common complication of diabetes and a leading cause of end-stage renal disease, characterized by progressive kidney fibrosis and inflammation. The transforming growth factor-beta (TGF-β) signaling pathway plays a crucial role in the pathogenesis of diabetes nephropathy, and SMAD7 is a key negative regulator of this pathway. Recent studies have highlighted the involvement of miRNA in the progression of DN.

Optimising ovarian tumor classification using a novel CT sequence selection algorithm.

Gynaecological cancers, especially ovarian cancer, remain a critical public health issue, particularly in regions like India, where there are challenges related to cancer awareness, variable pathology, and limited access to screening facilities. These challenges often lead to the diagnosis of cancer at advanced stages, resulting in poorer outcomes for patients. The goal of this study is to enhance the accuracy of classifying ovarian tumours, with a focus on distinguishing between malignant and early-stage cases, by applying advanced deep learning methods.

Evaluation of wound healing active principles in the transdermal patch formulated with crude bio wastes and plant extracts against GSK-3 beta an study.

The wound-healing process is accelerated by inhibiting proteins that decelerate the wound-healing pathway. One of the active proteins involved in enhancing healing at the nuclear level and in gene expression is catenin. Inhibition of Glycogen Synthase Kinase 3β (GSK3 β) phosphorylates and degrades catenin via the downstream Wnt signalling pathway, thereby stabilizing catenin.

Microheater: material, design, fabrication, temperature control, and applications-a role in COVID-19.

Heating plays a vital role in science, engineering, mining, and space, where heating can be achieved via electrical, induction, infrared, or microwave radiation. For fast switching and continuous applications, hotplate or Peltier elements can be employed. However, due to bulkiness, they are ineffective for portable applications or operation at remote locations.

Hepatitis C virus (HCV) diagnosis via microfluidics.

Humans are subjected to various diseases; hence, proper diagnosis helps avoid further disease consequences. One such severe issue that could cause significant damage to the human liver is the hepatitis C virus (HCV). Several techniques are available to detect HCV under various categories, such as detection through antibodies, antigens, and RNA.