Publications by authors named "K Rothwell"
Coastal sediments are a key contributor to oceanic phosphorus (P) removal, impacting P bioavailability and primary productivity. Vivianite, an Fe(II)-phosphate mineral, can be a major P sink in nonsulfidic, reducing coastal sediments. Despite its importance, vivianite formation processes in sediments remain poorly understood.
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- * The study investigates how low molecular weight organic acids (LMWOAs) affect the oxidation of siderite in controlled experiments, comparing results with and without these acids.
- * Findings show that while pure siderite oxidizes rapidly, the presence of LMWOAs can preserve a significant amount, suggesting that a protective layer forms on the siderite surface to slow down its oxidation.
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- - Asciminib is a targeted treatment for BCR::ABL1 that minimizes side effects from disrupting other kinases, with a study of 49 patients showing it is generally well tolerated over a median follow-up of 14 months.
- - Most patients (59%) continued treatment, with only 12% stopping due to intolerance; however, treatment cessation was primarily due to intolerance rather than drug resistance (65% vs. 35%).
- - Out of 44 patients evaluated, 66% achieved a complete cytogenetic response, with lower success rates seen in patients with specific genetic variants; further analysis indicated that the drug can influence the growth of certain resistant cancer cell populations.
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- The study examines the likelihood of treatment-free remission (TFR) among Chronic Myeloid Leukemia (CML) patients with different chromosomal characteristics.
- It categorizes patients into groups based on additional chromosomal abnormalities (ACA/Var-Ph group), those with only the classical Philadelphia translocation (c-Ph group), and high-risk ACA (HR-ACA subgroup) or variant Philadelphia translocations (Var-Ph subgroup).
- Findings aim to uncover how these chromosomal variations impact the probability of achieving TFR in CML patients, which is important for treatment decisions.
Structural Fe in clay minerals is an important, potentially renewable source of electron equivalents for contaminant reduction, yet our knowledge of how clay mineral Fe reduction pathways and Fe reduction extent affect clay mineral Fe(II) reactivity is limited. Here, we used a nitroaromatic compound (NAC) as a reactive probe molecule to assess the reactivity of chemically reduced (dithionite) and Fe(II)-reduced nontronite across a range of reduction extents. We observed biphasic transformation kinetics for all nontronite reduction extents of ≥5% Fe(II)/Fe(total) regardless of the reduction pathway, indicating that two Fe(II) sites of different reactivities form in nontronite at environmentally relevant reduction extents.
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