A qualitative study of the barriers to commissioning social and therapeutic horticulture in mental health care.

Background: Social and Therapeutic Horticulture (STH) is a process where trained practitioners work with plants and people to improve an individual's physical and psychological health, communication and thinking skills. Evidence suggests that STH can support individuals with mental ill-health, however, current commissioning of STH within mental health care is limited. This study aimed to understand the barriers to commissioning STH in mental health care and to identify potential solutions to barriers, to support more widespread availability of services.

Simulations of nutrient emissions from a net cage aquaculture system in a Brazilian bay.

Hydrodynamics and transport simulations were conducted with the modeling software TELEMAC-2D on Icó-Mandantes bay, a branch of the Itaparica reservoir. The bay has a maximal operational water level amplitude of 5 m and is suffering from eutrophication and algae bloom. Therefore, we investigated low and high water level scenarios with two different high resolution meshes, with the purpose to deeper understand their impact on transport of substances and to improve the watershed management.

Orally available and efficacious α4β1/α4β7 integrin inhibitors.

A series of potent α4β1/α4β7 integrin inhibitors is reported, including an inhibitor 12d with remarkable oral exposure and efficacy in rat models of rheumatoid arthritis and Crohn's disease.

PEG conjugates of potent α4 integrin inhibitors, maintaining sustained levels and bioactivity in vivo, following subcutaneous administration.

Mitsunobu reactions were employed to link t-butyl esters of α4 integrin inhibitors at each of the termini of a three-arm, 40 kDa, branched PEG. Cleavage of the t-butyl esters using HCO2H provided easily isolated PEG derivatives, which are potent α4 integrin inhibitors, and which achieve sustained levels and bioactivity in vivo, following subcutaneous administration to rats.