Publications by authors named "K Rosengren"
Article Synopsis
- Insulin-like peptide 5 (INSL5) primarily targets the RXFP4 receptor found in the colorectum and has potential for treating gastrointestinal issues like constipation.
- While INSL5 can bind to the RXFP3 receptor, it does not activate it, highlighting the specificity of the INSL5/RXFP4 pathway for therapeutic applications.
- The study developed an engineered INSL5 analogue (A13:B7-24-GG) that features a simpler structure, resulting in easier synthesis and improved potency and selectivity compared to native INSL5, making it a strong candidate for constipation treatment.
Article Synopsis
- Recifin A is a newly discovered peptide characterized by a distinctive "tyrosine-lock" structure that includes a four-stranded β-sheet stabilized by disulfide bonds.
- Researchers successfully synthesized recifin A using native chemical ligation of two fragments, finding that even in its linear form, it can adopt the complex fold easily.
- Five analogues of recifin A were created to study the importance of the central tyrosine residue and its role in inhibiting the cancer-related enzyme tyrosyl-DNA phosphodiesterase I.
Introduction: Infective endocarditis (IE) is a challenging diagnosis to suspect and to confirm. The purpose of this study was to clarify how often IE is suspected already on hospital admission, which clinical signs trigger the physicians' suspicions and to investigate if the empirical treatment is adequate.
Methods: A retrospective observational study of cases with definitive IE, during 2018-2019 in Skåne Region, Sweden was performed.
Question-asking is a crucial tool for acquiring information about unseen entities, such as viruses; thus, examining children's questions within the context of COVID-19 is particularly important for understanding children's learning about the coronavirus. The study examined 3-12-year-old children's questions and teachers' responses about the COVID-19 pandemic in Türkiye, a non-Western developing context, and the United States, a Western cultural context. A total of 119 teachers from Türkiye and 95 teachers from the US participated in the study.
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