Publications by authors named "K Ronnie Rex"
Article Synopsis
- The study outlines a 10-year quality improvement program for surgical stabilization of rib fractures (SSRF) at a Level 1 trauma center to improve patient outcomes and ensure safety.
- The research involved a review of cases from 2022, focusing on various data points like patient demographics, complications, and rib fracture specifics for 82 identified patients, where 88% underwent SSRF.
- Results indicated that SSRF patients had a 15% mortality rate, with notable complications linked to factors like the number of ribs stabilized and trauma severity, emphasizing the need for ongoing scrutiny in surgical practices.*
Free (unbound) drug concentration at the site of action is the key determinant of biologic activity since only unbound drugs can exert pharmacological and toxicological effects. Unbound drug concentration in tumors for solid cancers is needed to understand/explain/predict pharmacokinetics, pharmacodynamics, and efficacy relations. Fraction unbound ( ) in tumors is usually determined across several xenografted tumors derived from various cell lines in the drug discovery stage, which is time consuming and a resource burden.
View Article and Find Full Text PDFConsidering the extensive agricultural practices along the perennial rivers, viz. Periyar and Bharathappuzha of Kerala in the southwest coast of India, the first comprehensive surveillance of new and legacy organochlorine pesticides (OCPs) in surface sediment was conducted. Further, the sediment-water exchange fluxes have been elucidated.
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- Autoimmune liver diseases, although serious, are under-researched in Arctic native populations, prompting a study in Greenland to assess their prevalence and management.
- The study found an overall prevalence of 24.6 per 100,000, with specified cases of autoimmune hepatitis, primary biliary cholangitis, and overlap disease, but no cases of primary sclerosing cholangitis.
- Treatments followed internal guidelines, achieving complete or partial remission for most patients, although some progressed to cirrhosis, indicating a lower prevalence compared to Scandinavia and Alaska Inuit populations.
For more than a decade, Chennai city in southern India has been evidenced with informal electronic waste (e-waste) recycling and open burning practices as the potential sources for polychlorinated biphenyls (PCBs). PCBs can bioaccumulate in livestock particularly cows grazing on the contaminated soil. The outbreak of the COVID-19 pandemic led to additional challenges associated with waste management practices.
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