Sex dependence of naphthyl butyrate esterase activity in rat serum.

The effect of gonadectomy and sex hormone substitution on the activity of naphthyl butyrate esterase in rat serum was investigated. This enzyme was found to be strongly oestrogen-dependent.

[Early detection of alcoholic liver cell damage by the fructose stress test].

After regular intake lasting for years also a relatively slight quantity of alcohol may cause liver lesions, so that also for so-called social habitual drunkards an endangering can be taken into consideration. The fructose tolerance with the hyperlactaemia connected with this seems to be suitable for the early recognition of the liver cell lesions, since first intracellular metabolic disturbances can be proved.

Concentration dependence of the embryotoxic effects of benzene inhalation in CFY rats.

CFY rats were exposed to continuous benzene inhalation 24 h/day from day 7 to day 14 of gestation at 150, 450, 1500, or 3000 mg/m3 (50, 150, 500, or 1000 ppm) atmospheric concentrations. None of the benzene concentrations used proved to be teratogenic. There was no increase in the incidence of external, visceral, or skeletal malformations.