Publications by authors named "K Rode"
Immunotherapy is a cutting-edge approach that leverages sophisticated technology to target tumor-specific antibodies and modulate the immune system to eradicate cancer and enhance patients' quality of life. Bioinformatics and genetic science advancements have made it possible to diagnose and treat cancer patients using immunotherapy technology. However, current immunotherapies against cancer have limited clinical benefits due to cancer-associated antigens, which often fail to interact with immune cells and exhibit insufficient therapeutic targeting with unintended side effects.
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- Environmental changes due to global warming are increasing the transmission of pathogens and parasites in Arctic wildlife, particularly polar bears, which serve as key indicators of these shifts.
- A study found that the prevalence of several pathogens in Chukchi Sea polar bears increased significantly between two time periods (1987-1994 and 2008-2017), although increased land use in summer by bears did not correlate with higher exposure levels.
- Female polar bears showed higher antibody prevalence for some pathogens, possibly linked to their terrestrial denning habits, and overall findings suggest a need for further research to monitor disease signs in polar bears, which are affected by climate change and serve as a food source for local communities.
Flavonoids are polyphenolic compounds that have multiple benefits in treating various life-threatening diseases. Despite their diverse pharmacological activities, the market potential of flavonoids is hampered due to their poor solubility and low bioavailability after oral administration. The current review highlights the role of co-crystals and co-amorphous systems (CAMs) in enhancing the solubility, permeability, bioavailability, and therapeutic efficacy of flavonoids.
View Article and Find Full Text PDFAmong polar bears (), only parturient females den for extended periods, emerging from maternal dens in spring after having substantially depleted their energy reserves during a fast that can exceed 8 months. Although den emergence coincides with a period of increasing prey availability, polar bears typically do not depart immediately to hunt, but instead remain at the den for up to a month. This delay suggests that there are likely adaptive advantages to remaining at the den between emergence and departure, but the influence of the timing and duration of this post-emergence period on cub survival has not been evaluated previously.
View Article and Find Full Text PDFThe diets of the eight species of ursids range from carnivory (e.g., polar bears, Ursus maritimus) to insectivory (e.
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