Ischemic retinopathies including diabetic retinopathy are major causes of vision loss. Inner blood-retinal barrier (BRB) breakdown with retinal vascular hyperpermeability results in macular edema. Although dysfunction of the neurovascular unit including neurons, glia, and vascular cells is now understood to underlie this process, there is a need for fuller elucidation of the underlying events in BRB dysfunction in ischemic disease, including a systematic analysis of myeloid cells and exploration of cellular cross-talk.
View Article and Find Full Text PDFHuman feline leukaemia virus subgroup C receptor-related proteins 1 and 2 (FLVCR1 and FLVCR2) are members of the major facilitator superfamily. Their dysfunction is linked to several clinical disorders, including PCARP, HSAN and Fowler syndrome. Earlier studies concluded that FLVCR1 may function as a haem exporter, whereas FLVCR2 was suggested to act as a haem importer, yet conclusive biochemical and detailed molecular evidence remained elusive for the function of both transporters.
View Article and Find Full Text PDFRaising the speed and accuracy of displacement retrieval by overcoming the weakness of time-consuming parameter estimation and a complex displacement retrieval algorithm is of key importance in improving the real-time quality of optical feedback self-mixing-based displacement measurement sensor. This paper proposes a high-speed and accurate simultaneous estimation method of displacement, optical feedback factor, and linewidth enhancement factor based on data fitting near a half-fringe cooperating with the fringe-counting method. The displacement measurement accuracy of the proposed method is about 16 nm.
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