Technetium and Rhenium Schiff Base Compounds for Nuclear Medicine: Syntheses of Rhenium Analogues to Tc-Furifosmin.

Rhenium, the third-row congener of technetium, is often used to develop the macroscopic chemistry of potential Tc diagnostic radiopharmaceuticals. The rhenium analogues to Tc-furifosmin are being developed for potential radiotherapy of multidrug-resistant tumors. Complexes of the form trans-[M(PR)(NO-Schiff base)] are of interest for the potential imaging and treatment of multidrug-resistant tumors.

Pertechnetate-Induced Addition of Sulfide in Small Olefinic Acids: Formation of [TcO(dimercaptosuccinate)] and [TcO(mercaptosuccinate)] Analogues.

Technetium-99 (Tc) is important to the nuclear fuel cycle as a long-lived radionuclide produced in ∼6% fission yield from U or Pu. In its most common chemical form, namely, pertechnetate (TcO), it is environmentally mobile. In situ hydrogen sulfide reduction of pertechnetate has been proposed as a potential method to immobilize environmental TcO that has entered the environment.

Improving residency training in arthroscopic knee surgery with use of a virtual-reality simulator. A randomized blinded study.

Background: There is a paucity of articles in the surgical literature demonstrating transfer validity (transfer of training). The purpose of this study was to assess whether skills learned on the ArthroSim virtual-reality arthroscopic knee simulator transferred to greater skill levels in the operating room.

Methods: Postgraduate year-3 orthopaedic residents were randomized into simulator-trained and control groups at seven academic institutions.

Evaluation of skill level between trainees and community orthopaedic surgeons using a virtual reality arthroscopic knee simulator.

Background: Several virtual reality simulators have been developed to assist orthopaedic surgeons in acquiring the skills necessary to perform arthroscopic surgery. The purpose of this study was to assess the construct validity of the ArthroSim virtual reality arthroscopy simulator by evaluating whether skills acquired through increased experience in the operating room lead to improved performance on the simulator.

Methods: Using the simulator, six postgraduate year-1 orthopaedic residents were compared with six postgraduate year-5 residents and with six community-based orthopaedic surgeons when performing diagnostic arthroscopy.

Novel rhenium(III, IV, and V) tetradentate N2O2 Schiff base mononuclear and dinuclear complexes.

Reaction of (Bu4N)[ReOCl4] with the tetradentate Schiff base ligand α,α'-[(1,1-dimethylethylene)dinitrilo]di-o-cresol (sal2ibnH2) yields cis-[Re(V)OCl(sal2ibn)], which quickly forms trans-[μ-O(Re(V)O(sal2ibn))2] in solution. The dinuclear complex can also be isolated by the addition of base (Et3N) to the reaction mixture. Conversely, the mononuclear complex can be trapped as cis-[Re(V)O(NCS)(sal2ibn)] by addition of (Bu4N)SCN to the reaction mixture.