Publications by authors named "K Reetz"
Background: Physical activity and fitness are major targets in Alzheimer's disease (AD) preventive research. However, current research is heterogeneous and often disregards the relationship between these parameters and disease outcomes.
Objective: To assess the effects of physical activity and fitness on AD within the context of a multicomponent sports intervention.
Background: Friedreich ataxia is a rare neurodegenerative disorder caused by frataxin deficiency. Both underweight and overweight occur in mitochondrial disorders, each with adverse health outcomes. We investigated the longitudinal evolution of anthropometric abnormalities in Friedreich ataxia and the hypothesis that both weight loss and weight gain are associated with faster disease progression.
View Article and Find Full Text PDFIntroduction: Friedreich Ataxia (FA) is a multisystem neurodegenerative disease. Affected individuals rely on mobility assistive technologies (MAT) (e.g.
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- The study investigated cognitive impairments in cerebellar disorders and identified two subtypes of cerebellar cognitive affective syndrome (CCAS) using cluster analysis.
- The German CCAS-Scale was utilized to assess 205 cerebellar patients and 200 controls, revealing one cluster with severe cognitive impairment and another with milder deficits that often overlapped with healthy controls.
- Findings suggest that cognitive performance in cerebellar patients is influenced by both demographic factors and cluster assignment, indicating that the assessment tool may struggle to detect milder impairments.
Introduction: Knowledge about the distribution and frequency of the respective haplotypes on the wildtype and mutant allele is highly relevant in the context of future gene therapy clinical studies in Spinocerebellar Ataxia Type 3, the most common autosomal dominantly inherited ataxia. Single nucleotide polymorphisms associated to the disease-causing gene, ATXN3, have been determined. We wanted to investigate the frequency and regional distribution of two intragenic single nucleotide polymorphisms (SNPs) in a large European SCA3 cohort and their relation to the clinical phenotype.
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