Publications by authors named "K Rechendorff"
Robust devices for chronic neural stimulation demand electrode materials which exhibit high charge injection ( ) capacity and long-term stability. Boron-doped diamond (BDD) electrodes have shown promise for neural stimulation applications, but their practical applications remain limited due to the poor charge transfer capability of diamond. In this work, we present an attractive approach to produce BDD electrodes with exceptionally high surface area using porous titanium nitride (TiN) as interlayer template.
View Article and Find Full Text PDFObjective: The goal of this study was to assess the electrochemical properties of boron-doped diamond (BDD) electrodes in relation to conventional titanium nitride (TiN) electrodes through in vitro and in vivo measurements.
Approach: Electrochemical impedance spectroscopy, cyclic voltammetry and voltage transient (VT) measurements were performed in vitro after immersion in a 5% albumin solution and in vivo after subcutaneous implantation in rats for 6 weeks.
Main Results: In contrast to the TiN electrodes, the capacitance of the BDD electrodes was not significantly reduced in albumin solution.
Article Synopsis
- The study examined how fibrous encapsulation impacts the electrochemical properties of porous titanium nitride electrodes in a living organism (in vivo).
- Electrochemical impedance spectroscopy (EIS) was used to monitor inflammation and healing, revealing that the encapsulation lasted 3-4 weeks, during which voltage transients (VTs) increased and charge storage capacity (CSC) decreased.
- The findings suggest that the changes in VTs and CSC are linked to the healing process, and that traditional methods may underestimate the limits of charge injection during encapsulation.
Objective: To determine whether changes in electrochemical properties of porous titanium nitride (TiN) electrodes as a function of time after implantation are different from those of smooth TiN electrodes.
Approach: Eight smooth and 8 porous TiN coated electrodes were implanted in 8 rats. Before implantation, voltage transients, cyclic voltammograms and impedance spectra were recorded in phosphate buffered saline (PBS).
The in vivo electrochemical behavior of titanium nitride (TiN) nerve stimulation electrodes was compared to their in vitro behavior for a period of 90 days. Ten electrodes were implanted in two Göttingen minipigs. Four of these were used for electrical stimulation and electrochemical measurements.
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