Unveiling the Role of Mechanistic Target of Rapamycin Kinase (MTOR) Signaling in Cancer Progression and the Emergence of MTOR Inhibitors as Therapeutic Strategies.

The mechanistic target of rapamycin kinase (MTOR) is pivotal for cell growth, metabolism, and survival. It functions through two distinct complexes, mechanistic TORC1 and mechanistic TORC2 (mTORC1 and mTORC2). These complexes function in the development and progression of cancer by regulating different cellular processes, such as protein synthesis, lipid metabolism, and glucose homeostasis.

Pain Management in the Older Adults: A Narrative Review.

With the increase in life expectancy in the United States, octogenarians and nonagenarians are more frequently seen in clinical practice. The older adults patients have multiple preexisting comorbidities and are on multiple medications, which can make pain management complex. Moreover, the older adults population often suffers from chronic pain related to degenerative processes, making medical management challenging.

Quantification of using real-time polymerase chain reaction in subjects suffering from chronic periodontitis with and without rheumatoid arthritis.

Background: , highly virulent bacteria, is said to play an important role in the pathogenesis of periodontal disease and rheumatoid arthritis (RA). Chronic periodontitis (CP) is a microbial-induced inflammatory disease leading to tooth loss if undetected and untreated. RA is a systemic inflammatory disease affecting the joints with subsequent morbidity and mortality.

A comparison of steroid dose with or without local anesthetic in lumbar interlaminar epidural steroid injections.

Introduction: Epidural steroid injections (ESIs) are commonly used as a treatment for lumbar radiculopathy. Currently, most research on comparative efficacy of various steroids in epidural steroid injections is focused on transforaminal ESIs (TFESIs). Through this study, we aimed to compare various steroid doses with or without local anesthetic in interlaminar ESIs (ILESIs).