Ethanol Regulates Presynaptic Activity and Sedation through Presynaptic Unc13 Proteins in .

Ethanol has robust effects on presynaptic activity in many neurons, however, it is not yet clear how this drug acts within this compartment to change neural activity, nor the significance of this change on behavior and physiology . One possible presynaptic effector for ethanol is the Munc13-1 protein. Herein, we show that ethanol binding to the rat Munc13-1 C1 domain, at concentrations consistent with binge exposure, reduces diacylglycerol (DAG) binding.

Functionalized Polysilsesquioxane-Based Hybrid Silica Solid Amine Sorbents for the Regenerative Removal of CO2 from Air.

Functionalized polysilsesquioxane-based hybrid silica materials are presented as solid amine sorbents for direct CO2 capture from air. The sorbent was synthesized from amine and vinyl functionalized alkoxysilanes by a simple, energy efficient, and cost-effective co-condensation method. The material, containing bound amine functionalities, was found to have a selective CO2 capturing capacity of 1.